As expected, we observed that laminar shear stress induces cell shape change (Figure 1A), up‐regulates vasoprotective genes (such as CPY1B1, THBD and NOS3) and, however, down‐regulates pro‐atherosclerosis genes (such as VCAM1, CD36, and ANGPT2) (Figure 1B). The gene discussed is NOS3; the disease is atherosclerosis.