From listed above [IREB2 Iron regulatory protein 2 (Wang 2014b)], HK2 [Hexokinase 2 (Wang 2014a)], TOP2A [DNA topoisomerase 2-alpha (Yeo 2016)] and FASN [fatty acids synthase, (Berkers et al. 2013)] play crucial role in cellular proliferation and transformation and their expression is up-regulated in p53-dependent cancers. This evidence concerns the gene IREB2 and cancer.