PARP1 and sarcoma: Of these drugs, TMZ induces SSBs and causes increased PARP trapping when combined with a PARPi (Murai et al. 2014), and combination therapy of PARPi with TMZ has shown promising results in vitro and in vivo in other sarcomas, such as Ewing sarcoma, desmoplastic small round cell tumors and chordoma (Smith et al. 2015; Cao et al. 2019; van Erp et al. 2020).