In case 12, 18q21.33 deletion contain the exon 16–31 of PIGN, homozygous mutations in this gene lead to multiple congenital abnormalities-hypokalemia-epilepsy syndrome, the clinical phenotype is lack of motor development, seizures, multiple malformations and various congenital abnormalities involving the heart, urinary and gastrointestinal systems. This evidence concerns the gene PIGN and Hypokalemia.