Although this study demonstrated the positive relationship between mPGES-1/PGE2 and PD-related peritoneal fibrosis and the beneficial effect of the inhibition of mPGES-1 on the production of extracellular matrix proteins in RPMCs, the therapeutic effect targeting mPGES-1 were not evaluated in the PD animal model. This evidence concerns the gene PTGES and Peritoneal Fibrosis.