Cytochrome c oxidase subunit 5A (COX5A) was co-expressed with ALKBH5 and other m6A regulators, which play critical roles in hsa00190:Oxidative phosphorylation, hsa01100:Metabolic pathways, hsa04260:Cardiac muscle contraction, hsa04932:Non-alcoholic fatty liver disease (NAFLD), hsa05010:Alzheimer’s disease, hsa05012:Parkinson’s disease, and hsa05016:Huntington’s disease. Here, COX5A is linked to early-onset autosomal dominant Alzheimer disease.