Further studies have shown that m6A methylated RNA and METTL3 levels are consistently higher in liver tissues of patients with T2DM than in controls; hepatocyte-specific knockout of METTL3 in mice fed with a high-fat diet (HFD) increases insulin sensitivity and decreases fatty acid synthesis (Xie et al., 2019). This evidence concerns the gene METTL3 and type 2 diabetes mellitus.