They were enriched in “epidermal growth factor receptor (EGFR) signaling,” “insulin receptor signaling,” “MAPK1/MAPK3 signaling,” and “RAF/MAP kinase signaling.” Genetic interaction analyses of enhancers and protein-coding genes suggested that EGFR might be a novel susceptibility gene for T2DM (Yang et al., 2020). The gene discussed is INSR; the disease is type 2 diabetes mellitus.