Taken together, we summarize the main in vivo findings as follows: CRT serves as a critical ‘eat‐me’ signal to mediate apoV efferocytosis by liver macrophages after systemic infusion; apoV engulfment alleviates macrophage infiltration and promotes macrophage polarization towards anti‐inflammation phenotype; functional efferocytosis of apoVs provides an effective strategy for T2D counteraction and therapy (Figure 10). Here, CALR is linked to type 2 diabetes mellitus.