Under overnutrition condition, activated pro‐inflammatory KCs initiate the inflammation and induce the infiltration of MoMFs which display highly pro‐inflammatory phenotype and lead to insulin resistance as well as hepatic steatosis (Kazankov et al., 2019; Lee et al., 2018; Morinaga et al., 2015). The gene discussed is TBCE; the disease is Hepatic steatosis.