CASP4 and neoplasm: In addition, we recently demonstrated that IL-1α, as well as IL-18 and IL-33 (unpublished data), is present in higher levels in the blood and tissues of non-small cell lung cancer (NSCLC) patients, strictly correlated to the levels of tumor-associated caspase-4 [11], that we identified as a novel oncoprotein for NSCLC [16, 17].