For the 219 patients with biopsy-proven SCCA at the time of initial CEA measurement at our institution, 39 (18%) were newly diagnosed/non-metastatic, 17 (8%) with no evidence of disease following chemoradiation, 16 (7%) patients with recurrent/resectable disease, 19 (9%) with locally advanced/unresectable disease, 17 (8%) with metastatic disease to lymph nodes only, and 91 (41%) with metastatic disease to distant organs at the time of the initial CEA measurement. Here, CEACAM5 is linked to metastatic neoplasm.