The pathway analysis results (Table 3E and Figure 5A) showed that normal tissue Treg and non-tumor diseased tissue Treg shared seven upregulated caspase-1 secretomic gene pathways including pathways in cancer, vesicle organization, negative regulation of apoptotic signaling, myeloid leukocyte activation, striated muscle cell differentiation, cell morphogenesis, and supramolecular fiber organization. This evidence concerns the gene CASP1 and cancer.