PD-1 Does but CTLA-4 Does Not, Play Significant Roles in Promoting Treg Upregulated Genes in Normal Tissue and Non-Tumor Diseased Tissue Tregs; and Tumor Splenic and Tumor Tregs Have Certain CTLA-4-, and PD-1-, Non-Collaboration Transcriptomic Changes With Innate Immune Dominant Pathways. Here, PDCD1 is linked to neoplasm.