Taken together, these results have demonstrated that 1) lymphoid tissue Treg secretomes carry four inflammation-related functions such LPS/IL-1, IL6 signaling, type I diabetes signaling and p38 MAPK signaling; 2) VAT Treg play significant roles in Toll-like receptor signaling and leukocyte extravasation signaling; and 3) regeneration kidney Treg secretomic genes play critical roles in promoting kidney regeneration. Here, IL6 is linked to type 1 diabetes mellitus.