These kidney Treg-specific pathways include: reelin signaling, white adipose tissue browning, glioblastoma multiform, STAT3, IL-8, Rho GTPases, apelin liver, role of NFAT in cardiac hypertrophy, Wnt/Ca2+, PDGF, cholecystokinin/gastrin, adrenomedullin, IL-15 production, estrogen receptor, IL-6, phospholipase C and endothelin-1. The gene discussed is ESR1; the disease is cardiac hypertrophy.