In addition, normal spleen Treg, normal tissue Treg, non-tumor diseased spleen Treg, non-tumor diseased tissue Treg, tumor spleen Treg and tumor Treg had 8, 10, 2, 9, 11, and 9 specific upregulated caspase-4 secretomic pathways, respectively. The gene discussed is CASP4; the disease is neoplasm.