CD28 and cancer: As shown in Figure 2F, 52 upregulated pathways were shared by Treg from normal tissues and non-malignant disease tissues and 11 pathways were downregulated in Treg from normal tissues and non-malignant disease tissues including Th1 pathway, RhoGDI signaling, GPCR-mediated integration of enteroendocrine signaling, PPAR signaling, antioxidant action of vitamin C, IL-23 signaling, glutamate receptor, PTEN, cross-talk between dendritic cells and natural killer cells, CD28 signaling, and iCOS-iCOSL signaling.