EDN1 and osteoarthritis: As shown in Figure 2E, 12 pathways were shared by Treg from spleens of mouse bearing tumors and Treg from tumor tissues including TREM1, Vitamin C transport, T cell exhaustion, endothelin-1, PI3K signaling, Th2 pathway, thrombin, kinetochore metaphase, pancreatic adenocarcinoma, phospholipase C, integrin, and osteoarthritis.