Eleven pathways were tumor-bearing spleen Treg-specific including inflammasome, Toll-like receptor, colorectal cancer metastasis, cardiac hypertrophy, Rac, epithelial-mesenchymal transition, iNOS, MIF-mediated glucocorticoid regulation, dendritic cell maturation, inositol (1,4,5)-triphosphate biosynthesis, and adrenomedullin. The gene discussed is ADM; the disease is colorectal cancer.