When overlapping the TFs enriched in B-3, DC-2, and Monocyte-3 of SLE patients with the 157 TFs that could regulate genes to trigger T cell activity, we found 12 TFs with enriched binding sites in PBMC_SLE (FC >2), including four TFs in DC-2 (HNF1B, POU3F2, TFAP2A, and ZNF740) and eight TFs in B-3 (EWSR1-FLI1, MAF, MAFA, NFIB, NR2C2 (var. This evidence concerns the gene EWSR1 and systemic lupus erythematosus.