While both anti-IL-13 antibodies, Tralokinumab (55, 56) and Lebrikizumab (57) and both anti-IL-4 antibodies, Altrakincept (58) and Pascolizumab (59), failed to provide beneficial effects for patients with asthma, blocking signal transduction through IL-4- and IL-13-shared receptor complex with Dupilumab, a fully human monoclonal antibody against IL-4Rα, is efficient and is now approved for treatment of severe asthma patients (60–62). The gene discussed is IL4; the disease is asthma.