The indirect effect of ROS-mediated immunosuppressive TME includes the upregulation of PD-L1 by the tumor cells (Bailly, 2020; Raninga et al., 2020) as well enhanced expression of cytokines and chemokines that will recruit immunosuppressive myeloid cells (Bianchi et al., 2014; Eckert et al., 2018). The gene discussed is CD274; the disease is neoplasm.