NOS2 and central nervous system cancer: Several lines of evidence have showed that decreased proliferation of glioma cells could be mediated by selective inhibition of iNOS such as 1,400 W (N-(3-(aminomethyl) benzyl) acetamidine) (Fedorov et al., 2003) or mercapto-ethyl guanidine (MEG) (Southan et al., 1996) which inhibit the iNOS activity.