GAMs are recruited to the glioma microenvironment via the glioma cells’ release of chemoattractant: CCL2, CX3CL1, colony-stimulating factor (CSF-1), stromal cell-derived factor 1 (SDF-1), granulocyte/macrophage-colony stimulating factor (GM-CSF), and lysine oxidase (LOX) (Figure 2; Zhang et al., 2012; Roesch et al., 2018; Gutmann and Kettenmann, 2019; Chen et al., 2019). The gene discussed is CXCL12; the disease is central nervous system cancer.