CD8A and neoplasm: After coupling with Cytosine-phosphorothioate-guanine CpG oligonucleotide, a TLR-9 agonist, nanodiscs promoted co-delivery of Ag/CpG to lymphoid organs, eliciting strong neoantigen-specific anti-tumor CD8+ T-cell responses in murine models of melanoma and colon carcinoma.