INS and ischemic stroke: Ahsg is a plasma glycoprotein secreted mainly by the liver, which is associated with atherosclerotic calcification, insulin resistance, cardiovascular disease, and especially ischemic stroke (Weikert et al., 2008; Laughlin et al., 2012; Jiménez et al., 2014; Häring, 2016; Zhao et al., 2020).