xCT expression is enhanced in conditions of increased oxidative stress and/or inflammation, and inhibition of system xc− has been proposed as a treatment strategy for several neurological disorders as well as for diverse cancer types (Lewerenz et al., 2013; Massie et al., 2015; Koppula et al., 2018; Liu et al., 2020). The gene discussed is SLC7A11; the disease is nervous system disorder.