Therefore, this study aimed to evaluate the effects of different Colombian propolis extracts on the viability, lactate dehydrogenase (LDH) leakage, and apoptosis induction in canine OSA cells, particularly OSCA-8, by analyzing the expression of BAX, BCL-2, CASPASE 9, CASPASE 8, and TNFR1 genes. This evidence concerns the gene CASP8 and obstructive sleep apnea syndrome.