Glucagon-like peptide (GLP)-1 receptor agonists (GLP1-RAs) and dipeptidyl peptidase IV inhibitors (DPP-4is) are commonly used, widely approved agents for the management of glycemia among patients with type 2 diabetes, and are associated with weight loss (GLP1-RAs) or weight neutrality (DPP-4is). The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.