The most frequently reported AEs in the NB + incretin groups were nausea (24/345 [7.0%] for NB + DPP-4i and 32/339 [9.4%] for NB + GLP-1RA), vomiting (5/345 [1.4%] for NB + DPP-4i and 10/339 [2.9%] for NB + GLP-1RA), constipation (7/345 [2.0%] for NB + DPP-4i and 7/339 [2.1%] for NB + GLP-1RA), unstable angina (4/345 [1.2%] for NB + DPP-4i and 8/339 [2.4%] for NB + GLP-1RA) and tremor (4/345 [1.2%] for NB + DPP-4i and 8/339 [2.4%] for NB + GLP-1RA). This evidence concerns the gene GCG and angina pectoris.