Significant intra-dialytic changes were found in 2 MMPs (MMP3, MMP9), 2 TIMPs (TIMP1, TIMP2), no GFs, 1 clotting factor (vWF), 1 cardiovascular indicator (GAPDH), and no inflammatory indicators (Fig. 2). All measured proteases and proteolytic regulators decreased in a majority of HD patients, reflecting typical protein removal effects by mechanisms like membrane adsorption. This evidence concerns the gene MMP9 and Huntington disease.