CST3 and anemia (phenotype): In multivariable Cox regression analysis of the subsample, the final model incorporated the predictive factors age (HR; 95% CI: 1.60; 1.41–1.81), BMI (0.92; 0.88–0.95), smoking (1.58; 1.20–2.08), anemia (1.44; 1.05–1.97), cystatin C (1.27 per 0.3 mg/l; 1.16–1.39), CRP (1.45 per log(mg/l)-unit; 1.06–1.97), CCI (1.11; 1.06–1.15), and AZGP which demonstrated predictive value (HR per log-unit: 0.44; 0.24–0.8, p = 0.008, Fig. 1A).