ACE and autosomal dominant cerebellar ataxia: We took advantage of our previous RAND trial14 showing a beneficial effect of a 6 months angiotensin converting enzyme inhibitor (ACEI) treatment on macroalbuminuria in adult SCA patients at the time of hyperfiltration to study mGFR correlates with hemodynamic and biological parameters before and under renin-angiotensin system blocker, i.e. presumably in the setting of a normal or low filtration fraction.