In this way, significant association with QRS interval and amplitude as a surrogate of myocardial mass in European population41 and replication with SBP, DBP and also HTN using different criteria based on reference adjusted curves in the Iranian children and adolescents47, who was included in TCGS confirmation study is a signal for further investigations on the functional role of ZBED9 in BP regulation pathway in other populations. The gene discussed is SCAND3; the disease is hypertensive disorder.