After KPE, biomarkers predicting the prognosis may include (1) the serum IL-18 level to predict persistent jaundice; (2) APRi, postoperative serum HA and preoperative serum MMP-7 to predict significant liver fibrosis; and (3) APRi and postoperative serum M2BPGi to predict cirrhosis. This evidence concerns the gene MMP7 and Hepatic fibrosis.