AKT1 and cancer: However, our findings are also in concordance with others recent studies reporting that increase in cellular O2– and H2O2 by NADPH oxidase46 are leading the stimulation of cancer cell proliferation by ROS-sensitive AKT/ERK signaling pathways and the reduction of cancer cell growth by blocking this enzyme47; Dikalova et al. (2010) by using mitoTEMPO, they significantly reduced ROS in cells and inhibited NADPH oxidase activity46.