The same results were reported by Al-Hujaily et al. (2011) and Al-Howail et al. (2016) reporting that PAC could be considered as a powerful nontoxic new chemotherapeutic agent against ER-negative tumors by triggering breast cancer cell apoptosis more than curcumin21,24, downregulating ERα, c-Myc, cyclin D124 and inducing cell-cycle arrest at G2/M of this cancer cells21. This evidence concerns the gene MYC and breast carcinoma.