Morphological analysis of the tumors developed in the 11–13 months old Sox9-Pten livers revealed that the tumors developed are heterogeneous, consisting of both HCC (50%, 11 out of 22, supplemental Fig. 2l) and CCA/bile duct adenoma (BDA) (63.6%, 14 out of 22, supplemental Fig. 2n and o). This evidence concerns the gene PTEN and hepatocellular carcinoma.