RIPK3 and Patent ductus arteriosus: In contrast, the analysis of PDA in an experimental mouse model with RIPK3 deletion demonstrated a significantly increased number of CD4+ and CD8+ T cells but decreased number of FOXp3+, TAMs, and myeloid-derived suppressor cells (MDSC), indicating that deletion of RIPK3 was indeed associated with increased T cell infiltration and reduced immunosuppressive myeloid cells20.