IL33 and obesity due to melanocortin 4 receptor deficiency: The identification of molecular targets (TLR5) and mediators (TSLP, IL33 and Tregs) responsible for the immune regulatory effects of B. uniformis CECT 7771 in diet-induced obesity also provides new insights into the mechanism whereby effector human bacterial strains can work to attenuate the adverse impact of obesity in metabolic health.