LEP and obesity due to melanocortin 4 receptor deficiency: Negative correlations (q < 0.05) were observed between expression of TLR5 in either PP or EAT with obesity markers such as increased body weight gain, cholesterol, triglycerides, EAT weight, blood glucose and leptin as well as the blood pro-inflammatory markers IFNγ and IL-1α, while TLR5 from EAT positively correlated with anti-inflammatory makers IL-10 and TSLP from EAT (Fig. 5).