Indeed, KDM4A-9 correlates with the LSC17 score of AML samples and over 75% of KDM4A-9 high score fractions are LSC+ (Fig. 7A), therefore KDM4A-9 is a strong predictive indicator of AML-LSC activity (Fig. 7B). This evidence concerns the gene KDM4A and acute myeloid leukemia.