KDM4A and leukemia: Apoptosis results from a global accumulation of H3K9me3 and H3K27me3 at KDM4A genomic loci thereby causing downregulation of a KDM4A-PAF1-mediated oncogenic program, including a 9-gene signature enriched with leukemia stem cell (LSC) activity, which can stratify high-risk patients.