CD274 and glioblastoma: To explore this in more detail, we directly compared the immune cell subset abundances in GBM versus RCC using the edgeR algorithm.16 We found that nearly all subsets of T cells, plus NK cells, were decreased in the GBM TIME (figure 1B), consistent with prior reports.17 Using a second, myeloid-focused staining panel to compare GBM to RCC, we observed an increase in multiple TAM subsets in GBM, including a large population of PD-L1+ CD68+ TAMs (figure 1C).