CD274 and central nervous system cancer: Increased IFN-γ signaling is associated with a more favorable environment for PD-1 blockade.24 Profiling the TIME of these two glioma models by mass cytometry (online supplemental table S4), we found that the ICI-resistant SB28 model had fewer T cells and cDC2s (cluster 10), as well as more PD-L1+ TAMs than the ICI-responsive GL261 model (figure 1D).