KLK3 and bone metastasis: In multivariate analysis, we selected items that were considered clinically important according to previous reports [5, 6, 14, 15] or our univariate analysis, which included PSA levels ≥ 261 ng/mL, Gleason score ≥ 8, N stage, visceral metastasis, bone metastasis EOD ≥ 2, received BMA, and %PSA ≥ 1.