While it’s been reported that the demethylase FTO (alpha-ketoglutarate-dependent dioxygenase) coimmunoprecipitates with CRY1/2 [36], studies also showed that upregulation of FTO and CRY1 attenuated atherosclerosis through macrophages and proinflammatory factors respectively [37, 38]. This evidence concerns the gene MBD2 and atherosclerosis.