Ten modifiable risk factors for IS, in descending order of importance, are hypertension (HT), the apolipoprotein (Apo)B/ApoA1 ratio, physical activity, diet, the waist-to-hip ratio (WHR), psychosocial factors, smoking, cardiac causes, diabetes mellitus (DM), and alcohol consumption, all of which accounted for 91.5 and 95.2% of the population attributable risk (PAR) of IS worldwide and in China, respectively, as quantified by the INTERSTROKE investigators [3]. This evidence concerns the gene APOA1 and Hypertension.