This category of patients with ALK rearrangement has the following clinicopathological characteristics: Young age at diagnosis (a median of 50 years old), women gender, non-smokers/light smokers, histology of adenocarcinoma with particular morphologic patterns such as and cribriform and solid signet ring, expression of thyroid transcription factor 1, tendency to metastasize in pleura or pericardium, frequently with more metastatic sites than other molecular types, and predominant central nervous system (CNS) metastases [20-22]. Here, NKX2-1 is linked to adenocarcinoma.