The expression of metalloproteinase inhibitor 2 (TIMP2), one of the naturally occurring inhibitors of MMPs, was decreased in abdominal skin of hernia patients,13in fascia transversalis specimens of inguinal hernia patients,11and in the aneurysmal aortic wall.15These findings suggest an imbalance between the proteolytic activity of MMPs and their inhibitors in the abdominal skin prone to hernia formation and in the aortic wall with aneurysmal dilatation. This evidence concerns the gene TIMP2 and Hernia.