In contrast, expression levels of mRNA encoding endothelial adhesion molecules, i.e., VCAM-1 [NM_011693], ICAM-1 [NM_010493], and E-selectin [NM_011345], were significantly upregulated in the skin of WT mice, but not in that of RAGE-/- mice following infection with venestatin-knockdown larvae, compared with those infected with control larvae (p < 0.0001; Fig 7). This evidence concerns the gene SELE and infection.