Surprisingly, the BMT did not restore the CD43Hi blood monocyte population in the rescued Csf1rko rats whereas the granulocytosis and B cell deficiency in peripheral blood was completely resolved (Fig 12A–12F). The BM cavity was patent and the populations of IBA1+ hematopoietic island macrophages and TRAP+ osteoclasts were indistinguishable from WT litter mates (Fig 12G). Here, AIF1 is linked to B cell deficiency.