We firstly unveiled that NEAT1 was upregulated in MI resulting from CHD, and that the silencing NEAT1 reduced LVIDD, LVIDs, LVEF, LVFS, LVEDP and +dP/dt, infarct size, levels of IL-1β, IL-6, and IL-18, and inhibited cardiomyocyte apoptosis to alleviate myocardial injury. Here, IL1B is linked to coronary artery disorder.