As shown in Figure 3B, 3C, PD-1+ and LAG-3+ cell densities were higher in PD-L1+ tumor samples than in PD-L1− tumor samples (PD-1+: 47.3 ± 11.7 vs. 24.0 ± 4.5 cells/mm2; LAG-3+: 54.8 ± 10.7 vs. 29.1 ± 6.7 cells/mm2). This evidence concerns the gene CD274 and neoplasm.