CD274 and central nervous system cancer: KEGG pathway analysis of LncRNA-associated target genes identified several signalling pathways associated with genomic instability, tumorigenesis, progression and treatment of low-grade glioma including B cell receptor signalling pathway, T cell receptor signalling pathway, Rap1 signalling pathway, JAK-STAT signalling pathway, PD-L1 expression and PD-1 checkpoint signalling pathway, the Wnt signalling pathway, cAMP signalling pathway and cGMP-PKG signalling pathway (Figure 2G and 2H).