The findings of this study showed that lncRNA H19, AC091932.1, AC064875.1, AC010273.2, and AC131097.4 were negatively correlated with overall survival, whereas lncRNA FLG-AS1, AL138767.3, and ISX-AS1 were positively correlated with overall survival (p < 0.001), indicating they play a protective role in low-grade gliomas. Here, ISX is linked to central nervous system cancer.