With the recognitionof the role of the physical environment in cancer progression, mechano-basedtherapies that target increased tissue stiffness are emerging clinically.The therapies target the ECM itself by causing degradation (MMPs activationor bacterial collagenase) or inhibiting cross-linking (LOX inhibition).They can also target the integrins to limit cancer cell sensing ortarget the stromal cells. Here, LOX is linked to cancer.