TGFB1 and heart failure: For example, in a murine model of pressure overload–induced heart failure by transverse aortic constriction (TAC), myofibroblast-specific inhibition of transforming growth factor β (TGFβ) signaling attenuated cardiac fibrosis, providing evidence that activation of tissue-resident fibroblasts by TGFβ is responsible for the fibrotic response in the heart [11•].