SUV39H1 and diabetes mellitus: In parallel with these findings, it was reported that the levels of the H3K9me3 methyltransferase Suv39h1 were reduced in the db/db vs. the control cells; upon overexpression of Suv39h1, the inflammatory hyperstimulation state was reversed in the db/db VSMC, indicating that hyperglycemia and diabetes reversed a protective epigenetic histone modification signature in these cells [27].