Focusing on human macrophages, a distinct study reported that hyperglycemia increased the expression of S100A8 and S100A9 in macrophages and that expression of another S100/calgranulin, S100A12 (or EN-RAGE, a ligand of the receptor for advanced glycation end products [RAGE]) [35], was sustained in human macrophages after glucose levels were returned to euglycemia [36•]. This evidence concerns the gene S100A12 and Hyperglycemia.