In order to probe the underlying mechanisms, macrophages were sorted from the regressing plaques; in that study, CD45.1 macrophages were recipient-derived and CD45.2 macrophages were derived from the donor arches of the diabetic mice devoid of the Ldlr. RNA-seq experiments on the CD45.1 vs. CD45.2 macrophages linked RAGE-dependent mechanisms principally to the recipient macrophages and, for the first time, linked RAGE to interferon signaling in diabetes [51••]. Here, AGER is linked to diabetes mellitus.