PRKAA2 and Hyperglycemia: The consequences of hyperglycemia on inhibition of AMP-activated protein kinase A2 (AMPK-A2) on the induction of cardiomyopathy were recently traced to effects on mitochondria-associated endoplasmic reticulum membranes (MAMs), with particular focus on the roles of FUN14 domain containing 1 (Fundc1), which is an outer mitochondrial membrane protein and MAMs [61].