In this trial, the Diabetes Lifestyle Intervention using Technology Empowerment (D’LITE) study, we compared the effectiveness of a weight loss lifestyle intervention delivered using the app via in-app coaching by dietitians with usual care, focusing on body weight change and metabolic profiles among Asian patients with type 2 diabetes and overweight or obesity who were not receiving insulin. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.