EWSR1 and vascular malformation: Thus, EWSR1-NFATC2 rearrangement is another promiscuous gene fusion that can occur in a wide array of tumors: not only in malignant NFATC2-rearranged round cell sarcoma (with amplification of the fusion) and benign SBC (without amplification of the fusion), but now also in vascular malformation/hemangioma in elderly patients (Fig. 7).