While in SBC and in the 3 vascular malformations/hemangiomas with EWSR1-NFATC2 rearrangement reported here morphologic features of malignancy are lacking, this is in sharp contrast to NFATC2-rearranged round cell sarcoma which are undifferentiated and clinically aggressive tumors, and thereby overtly malignant. This evidence concerns the gene EWSR1 and vascular malformation.