APP and Alzheimer disease: Researchers have generated several mouse models carrying human amyloid protein precursor (APP) and/or presenilin (PSEN) transgenes with different AD‐linked mutations, including 5xFAD, APPswe/PSEN1dE9 (Garcia‐Alloza et al., 2006), APPswe/PSEN1(A246E) (Borchelt et al., 1997), Tg 2576 (Hsiao et al., 1996), etc., which develop Aβ deposits lacking pathogenic tau in the brain.