Taken together, our experimental analysis showed that dysregulation of the ceRNA circuit comprised of PRKCQ‐AS1, has‐miR‐545‐5p and STAT1 act as a vital regulatory role in JAK/STAT signalling pathway activation, which involve in the hyper‐inflammation of keratinocytes in psoriasis (Figure 5I). The gene discussed is PRKCQ; the disease is psoriasis.