CDC50A and intrahepatic cholestasis: Our previous studies have demonstrated that TMEM30A deficiency causes a series of disorders: retarded retinal angiogenesis, Purkinje cell, retinal bipolar cell and photoreceptor cell degeneration, impaired foetal liver erythropoiesis, intrahepatic cholestasis and chronic myeloid leukaemia (Liu et al., 2017; Zhang et al., 2019; Yang et al., 2018, 2019a, 2019b; Zhang et al., 2017; Li et al., 2018).