PRL and psychotic disorder: Prolactin levels were weakly correlated with ~4-6 mg/day daily dose of risperidone (r=0.328, p=0.001) and showed a trend towards being weakly associated with improvement of in psychosis assessed at baseline without treatment for 2-4 weeks and then again at 12 weeks of risperidone treatment (r=−0.329-0.51, p=0.016-0.094).40,41 Prolactin levels peaked within 2-4 weeks while BPRS scores continued to improve over the entire 12 weeks.41