Increased prolactin levels have been implicated as one of 51 SZ diagnostic biomarker for treatment naive subjects.42 In 14 postmortem brains from SZ subjects, prolactin levels were reduced by 46% relative to controls although only one of the two assessments were found significant.43 These findings warrant further investigation to determine whether prolactin levels are elevated in relation to physical/emotional stress during psychosis or if they are generally elevated in treatment-naïve subjects with SZ. The gene discussed is PRL; the disease is psychotic disorder.