Comparing these 27 genes to the top 20 most frequently mutated genes in human cancers (Cancer Genome Atlas; https://portal.gdc.cancer.gov/), four overlapping genes were identified, namely, PIK3CA, KRAS, APC, and NF1, which ranked 2nd, 6th, 10th, and 13th, respectively. This evidence concerns the gene PIK3CA and cancer.