TNNT2 and familial dilated cardiomyopathy: By using patient-specific hiPSC model, Sun et al. (2012) demonstrated that hiPSC-CMs carrying TNNT2 p.R173W mutation could partially recapitulate the disease phenotype of DCM, as indicated in altered regulation of calcium ion (Ca2+), decreased contractility, and abnormal distribution of sarcomeric α-actinin.