Consistently, nonsense mutations in BAG3 locus have been shown to cause BAG3 haploinsufficiency and disengagement of the BAG3-coordinated cardioprotective chaperone complex in hiPSC-CMs (Judge et al., 2017), which might be the pathologic mechanism of DCM-associated BAG3 mutation. The gene discussed is BAG3; the disease is familial dilated cardiomyopathy.