IDH1 and central nervous system cancer: Our earlier observation that B7H3 has a positive correlation with VEGFA inspired us to examine the expression of VEGFA in IDH1-R132H glioma cells and we found that VEGFA expression was significantly decreased accompanied by reduced B7H3 in IDH1-R132H U87 cells (Figure 5A), while was increased to the comparable level in IDH1-R132H/T77A cells compared with IDH1-WT U87 cells (Figure 5A).