To determine whether D-2-HG affects the expression of B7H3, we treated a glioma cell line U87 with cell-permeable D-2-HG at 1, and 2 mM for 24 h, and found that D-2-HG significantly decreased B7H3 protein level (Supplementary Figures 1A,B and Figure 2A). Here, CD276 is linked to central nervous system cancer.