MMP2 and central nervous system cancer: Considering that multiple growth factors and cytokines are involved in tumor angiogenesis (De Palma et al., 2017; Wang et al., 2020), we analyzed the interaction among B7H3 and 17 key angiogenesis-related growth factors and cytokines, including VEGFA, VEGFB, VEGFC, MMP2, PDGFA, PDGFB, PDGFC, PDGFD, FIGF, PIGF, PGF, FGF2, CXCL9, WNT7A, WNT7B, PECAM1, and THBS1 in gliomas by Circos and found that B7H3 was significant positively correlated with VEGFA and MMP2 as compared with the correlation between B7H3 and other angiogenesis-related factors (Figure 4A and Supplementary Figure 5).