Early reports focused on the expression and immune regulation of B7H3 on dendritic cells (DCs), monocytes (Chapoval et al., 2001), T cell inhibition (Pardoll, 2012; Chen et al., 2013; Vigdorovich et al., 2013), and also NK cells and invasive phenotype in GBM (Lemke et al., 2012). This evidence concerns the gene CD276 and glioblastoma.